A mutation in APP protects against Alzheimer/'s disease and age-related cognitive decline : Nature : Nature Publishing Group:
By highlighting the association between decreased APP processing and protection against Alzheimer’s disease, the research strongly supports the amyloid hypothesis, which has suffered recently, said Goate. “A lot of ongoing therapeutic work based on the amyloid hypothesis has failed,” she explained, “so people were worried that modulating amyloid might not work.” But the current study suggests that reducing amyloid β may play a role in preventing Alzheimer’s development. In addition, the data also support continued investigation of BACE inhibitors as possible therapeutic drugs to treat Alzheimer’s, she added
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